Toluene-2,4-diisocyanate 甲苯-2,4-二异氰酸酯

规格: 98%
CAS: 584-84-9
产品编号: H79512
MDL: MFCD00002011
品牌: INFI
Chemical NameToluene-2,4-Diisocyanate
CAS Number584-84-9
Synonym 2,4-二异氰酸酯 Hylene T Tolylene 2,4-diisocyanate SCURANATE T100 甲苯-2，4-二异氰酸酯 2，4-二异氰酸甲苯酯 2,4-二异酸甲苯酯 甲苯二异氰酸酯 2,4-TDI NCI 2,4-Toluylendiisocyanat SCURANATE TX 2,4-二异氰酸基甲苯 2,4-Diisocyan Tolylene-2,4-diisocyanate ######## Isocyanic acid, methylphen 1-METHYL-1,3-PHENYLENE DIISOCYA {Chemi TOLYLENE-2,4-DIISOCYANATE 4-Methyl- 2,6-Diisocyanat-toluol { C9H6N2O2 (2,4-diisocyanato-1-methyl-benzene) NSC 56759 4-Methyl-m-phenylene diisocyante TDI-80 2,4-Toluoldiisocyanat 甲代亚苯基
PubChem Substance ID87576243
EC Number209-544-5
Beilstein Registry Number13,138
MDL NumberMFCD00002011
Merck Number9530
Chemical Name Translation二异酸甲苯酯
Wiswesser Line NotationOCNR B1 ENCO
LabNetwork Molecule IDLN00195034
InChIInChI=1S/C9H6N2O2/c1-7-2-3-8(10-5-12)4-9(7)11-6-13/h2-4H,1H3
Reaxys-RN744602
GHS Symbol
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 56 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems
   Laboratory, NIOSH Exchange Chemicals.  (Aberdeen Proving Ground, MD 21010)
   Volume(issue)/page/year: NX#07807

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Bird - wild bird species
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AECTCV Archives of Environmental Contamination and Toxicology.
   (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ
   070944)  V.1-    1973-  Volume(issue)/page/year: 12,355,1983

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : >16 mL/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   UCDS** Union Carbide Data Sheet.  (Union Carbide Corp., 39 Old Ridgebury
   Rd., Danbury, CT 06817)  Volume(issue)/page/year: 3/8/1973

TYPE OF TEST            : TCLo - Lowest published toxic co

TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 13 ppm/4H
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - structural or functional change in trachea
   or bronchi
   Lungs, Thorax, or Respiration - changes in pulmonary vascular resistance
   Lungs, Thorax, or Respiration - pleu

TYPE OF TEST            :

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 300 mg/L
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   13,133,1989

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 100 ug/plate
REFERENCE :
   ENMUDM Environmental Mutagenesis.  (New York, NY)  V.1-9, 1979-87.  For
   publisher information, see EMMUEG.  Volume(issue)/page/year: 9(Suppl
   9),1,1987

TYPE OF TEST            : Specific locus test
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 75 mg/L
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   17,196,1991

WGK Germany2
Hazard Codes T+
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H317 May cause an allergic skin reaction 可能导致皮肤过敏
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H330 Fatal if inhaled 吸入致命
  • H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled 吸入可能导致过敏或哮喘症状或呼吸困难
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H351 Suspected of causing cancer 怀疑致癌
  • H412 Harmfutoaquaticlifewithlonglastingeffects 对水生生物有害并具有长期影响。
    Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
    RTECSCZ6300000
    Precautionary statements
    • P201 Obtain special instructions before use. 使用前获取专门指示。
    • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
    • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
    • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
    • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
    • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
    • P272 Contaminated work clothing should not be allowed out of the workplace. 污染的工作服不得带出工作场所。
    • P273 Avoid release to the environment. 避免释放到环境中。
    • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
    • P284 Wear respiratory protection.? 佩戴呼吸保护装置。
    • P302+P352+P333+P313+P362+P364
    • P304+P340+P310
    • P305+P351+P338
    • P305+P351+P338+P337+P313
    • P308+P311
    • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
    • P342+P311
    • P403+P233
    • P405 Store locked up. 上锁保管。
    • P501 Dispose of contents/container to..… 处理内容物/容器.....
      Signal word Danger
      UN Number 2078 UN 2078 6.1/PG 2 UN2078
      Risk Statements
      • R52/53
      • R26 Very toxic by inhalation 吸入极毒
      • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
      • R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
      • R42/43
        Safety Statements
        • S23 Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer) 不要吸入气体/烟雾/蒸汽/喷雾；
        • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
        • S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
        • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
          Storage condition 0-10°C 2-8°C Moisture Sensitive
          Packing GroupII
          Hazard Class6.1
          Warnings 危化品目录(2015) 危险化学品
        • Occupational asthma is the principal cause of work-related respiratory disease in the industrial world. Toluene-2,4-diisocyanate (TDI) is one of the most common respiratory sensitizers leading to occu
        • {TRC} Vanoirbeek, J., et al.: Toxicol. Sci., 2004, 80, 310 (2004),
        • {TRC} Crameri, R., et al.: Allergy, 60, 1227 (2005),
        • {TRC} Ku, H., et al.: Toxicol. Lett., 190, 231 (2009),
        • {SA}
        • 1. Biomaterials 16 , 51, (1995) 摘要
        • {SA}
        • {SA} 2. J. Incl. Phenom. Mol. Recog. Chem. 17 , 249, (1994)
        • {SA}
        • Merck 14 ,9530
        • {SA}
        • Beil. 13 ,IV,243
        • {SA}
        • Fieser 1 ,1171
        • {SA}
        • Aldrich MSDS 1 , 1720:A / Corp MSDS 1 (2), 3376:B / FT-IR 2 (2), 3199:B / FT-IR 1 (2), 478:B / IR-Spectra (3), 1144:B / IR-Spectra (2), 996:G / NMR-Reference 2 (2), 446:B / RegBook 1 (2), 2169:F / Sax 6 , 1083 / Sigma FT-IR 1 (2), 934:D / Structure Index 1 , 341:D:5 / Vapor Phase 3 , 1434:D
        • {uni_hamburg} Short: III/35D2
        • Title: Nuclear Magnetic Resonance (NMR) Data: Chemical Shifts for Carbon-13, Part 2: Aromatic Compounds
        • Author: Mikhova, B.
        • Editor: Gupta, R.R.; Lechner, M.D.
        • Source: Landolt-Börnstein, New Series
        • Volume: III/35D2
        • Year: 2005
        • Keyword: aromatic compounds; carbon-13; chemical shift; coupling constant; molecular structure
        • ISBN: 978-3-540-20189-2
        • ISBN: 3-540-20189-0
        • Internet Resource: DOI:10.1007/b83345
        • RefComment: VIII, 291 p., Hardcover
        • RefComment: Written for Science and engineers in the fields of physics, chemistry and physical chemistry who inted to use NMR to study the structure and the binding of molecules
        • Abstract: Nuclear Magnetic Resonance (NMR) is based on the fact that certain nuclei exhibit a magnetic moment, orient by a magnetic field, and absorb characteristic frequencies in the radiofrequency part of the spectrum. The spectral lines of the nuclei are highly influenced by the chemical environment i.e. the structure and interaction of the molecules. NMR is now the leading technique and a powerful tool for the investigation of the structure and interaction of molecules. The present Landolt-Börnstein volume III/35 Nuclear Magnetic Resonance (NMR) Data is therefore of
          • 584-84-9 H79512 Toluene-2,4-diisocyanate 甲苯-2,4-二异氰酸酯

          化学属性

          Mol. FormulaC9H6N2O2
          Mol. Weight174.16
          Boiling Point251°C(lit.)
          Density1.214
          Melting Point20-22 °C (lit.)
          Refractive indexn20/D 1.568(lit.)
          Flash Point132° (270°F)
          TSCAYes
          Autoignition Point>;1148 °F
          Vapor Density6 (vs air)
          Vapor Pressure0.03 mmHg ( 25 °C)
          Solubility起反应

          *以上化合物性质及应用等信息仅供参考