Benzotrifluoride 三氟甲苯

规格: 99%
CAS: 98-08-8
产品编号: H82048
MDL: MFCD00000372
品牌: INFI
Chemical NameBenzotrifluoride
Synonym α,α,α-Trifluortoluol 1,1,-trifluorotoluene 三氟苄 Benzylidyne fluoride 三氟甲基苯 trifluoromethyl-benzene omega-Trifluorotoluene α (trifluoromethyl)benzene 三氟甲苯 {Chemicalbook} Benzene,(t Toluene, α,α, α-trifluoro- Benzene, (trifluoromethyl)- benzylidynefluoride α,α,α-Trifluorotoluene {Chem benzenyl fluoride 三氟化次苄 {uni_hamburg} 苄川三氟 ,,-Trifluorotoluene ω,ω,ω-三氟甲苯 Benzenyl fluoride A,A,A-TRIFLUOROTOLUENE (trifluoromethyl)-benzen 三氟甲基苯,苯氟仿,苄川三氟 a,a,a-trifluorotolene ,,-Trifluorotoluene, (Trifluoromethyl)benzene benzen To α,α,
CAS Number98-08-8
PubChem Substance ID7368
MDL NumberMFCD00000372
EC Number202-635-0
Beilstein Registry Number5,290
Reaxys-RN1906908
Merck Number1110
Chemical Name Translation三氟甲苯
Wiswesser Line NotationFXFFR
LabNetwork Molecule IDLN00163130
InChIInChI=1S/C7H5F3/c8-7(9,10)6-4-2-1-3-5-6/h1-5H
GHS Symbol
TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 70810 mg/m3/4H
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single
   Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects,
   GKNT, 1982  Volume(issue)/page/year: -,25,1982

TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Mammal - species unspecified
DOSE/DURATION           : 92 gm/m3
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GTPZAB Gigiena Truda i Professional'nye Zabolevaniya.  Labor Hygiene and
   Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
   V.1-36, 1957-1992. For publisher information, see MTPEEI
   Volume(issue)/page/year: 30(3),6,1986

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: AD277-689

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSU

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 10000 mg/kg
TOXIC EFFECTS :
   Behavioral - general anesthetic
   Behavioral - excitement
   Behavioral - muscle weakness
REFERENCE :
   TPKVAL Toksiko

WGK Germany1
Hazard Codes F;N F,T
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H331 Toxic if inhaled 吸入中毒
  • H351 Suspected of causing cancer 怀疑致癌
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H372 Causes damage to organs through prolonged or repeated exposure 长期或频繁接触会损伤器官
  • H361d Suspected of damaging the unborn child 怀疑对未出生婴儿造成伤害
  • H411 Toxictoaquaticlifewithlonglastingeffects 对水生生物有毒性并具有长期影响。
  • H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
  • H304 May be fatal if swallowed and enters airways 吞食和进入呼吸道可能致命
  • H350 May cause cancer 可能致癌
  • H340 May cause genetic defects 可能导致遗传性缺陷
  • H373 May causes damage to organs through prolonged or repeated exposure 长期或频繁接触可能会损伤器官
    Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
    Precautionary statements
    • P304+P340+P312
    • P403+P233
    • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
    • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
    • P305+P351+P338
    • P501 Dispose of contents/container to..… 处理内容物/容器.....
    • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
    • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
    • P303+P361+P353
    • P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
    • P301+P310
    • P311 Call a POISON CENTER or doctor/physician. 呼叫解毒中心或医生/医师。
    • P241 Use explosion-proof electrical/ventilating/lighting/…/equipment. 使用防爆电气/通风/照明/ .../设备。
    • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
    • P273 Avoid release to the environment. 避免释放到环境中。
    • P281 Use personal protective equipment as required. 使用所需的个人防护装备。
    • P403+P235
    • P241+P242+P243
    • P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
    • P233 Keep container tightly closed. ?保持容器密闭。
      Signal word
      Safety Statements
      • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
      • S53 Avoid exposure - obtain special instructions before use 避免接触,使用前获得特别指示说明;
      • S23 Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer) 不要吸入气体/烟雾/蒸汽/喷雾;
      • S16 Keep away from sources of ignition - No smoking 远离火源,禁止吸烟;
      • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
      • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
      • S62 If swallowed, do not induce vomiting: seek medical advice immediately and show this container or label where possible 吞食后不要催吐:立即求医并出示该容器或标签;
      • S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中,参考特别指示/安全收据说明书;
        Risk Statements
        • R11 Highly flammable 非常易燃
        • R36/38 Irritating to eyes and skin 对眼睛和皮肤有刺激性
        • R46 May cause inheritable genetic damage 可能引起遗传基因损害
        • R45 May cause cancer 可能致癌
        • R48/23/24/25
        • R65 Harmful: may cause lung damage if swallowed 若吞咽可能伤害肺部器官
        • R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入,皮肤接触及吞食都有毒
        • R39/23/24/25 Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed 毒性:吸入,皮肤接触和吞食都会产生十分严重的不可逆危险
        • R51/53
        • R48/20/22
        • R38 Irritating to skin 刺激皮肤
        • R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
        • R22 Harmful if swallowed 吞咽有害
        • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
          RTECSXT9450000
          UN Number 2338
          Packing GroupII
          Hazard Class3
          Storage condition 储存温度2-8℃ 2-8°C
        • 医药;染料的中间体,溶剂。并用作硫化剂及绝缘油的制造。
        • {uni_hamburg} Short: II/25D
        • {ALF} Non-chlorinated alternative solvent to dichloromethane for a variety of reactions including Swern, Dess-Martin and hydrogen peroxide oxidations, and Lewis acid promoted reactions: J. Org. Chem., 62, 450 (1997).
        • {ALF} Metallation of benzotrifluoride with n-BuLi in diethyl ether is unselective, giving, on quenching with CO2, a mixture consisting largely of ortho- and meta-trifluoromethyl benzoic acids: J. Am. Chem. Soc., 68, 1658 (1946). Use of the superbasic combination of n-BuLi and KO-t-Bu was found to give regioselective ortho-metallation, leading to high yields of the ortho-acid: Synlett, 747 (1990).
        • {ALD} Merck: 14,1110
        • {uni_hamburg} Short: II/14a
        • {ALD} Merck: 14,1110
        • Beilstein:5,290
        • 98-08-8 H82048 Benzotrifluoride
三氟甲苯

          化学属性

          Mol. FormulaC7H5F3
          Mol. Weight146.11
          Density1.19
          Refractive index1.4140 to 1.4170
          Flash Point12°C(lit.)
          TSCAYes
          Boiling Point102°C
          Melting Point-29
          Solubility<0.1 G/100 ML AT 21 ºC
          Stability易吸潮