Benzhydrazide 苯甲酰肼

规格: 99%
CAS: 613-94-5
产品编号: H82899
MDL: MFCD00007596
品牌: INFI
Chemical NameBenzoylhydrazine
CAS Number613-94-5
Alfabeta NameBENZOICACIDHYDRAZIDE
MDL NumberMFCD00007596
Synonym Benzohydrazide {LY} Benzohydrazide {} {LY} Benzohydrazide {} {} {LY} Benzohydrazide {} {} {} {LY} Benzohydrazide {} {} {} {} {LY} Benzohydrazide {} {} {} {} {} {LY} Benzohydrazide {} {} {} {} {} {} {LY} Benzohydrazide {} {} {} {} {} {} {} {LY} Benzohydrazide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Benzohydrazide {} {} {} {} {} {} {} {} {} {LY} Benzohydrazide {} {} {} {} {} {} {} {} {} {} {LY} Benzohydrazide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Benzohydrazide {} {} {} {} {} {} {} {} {} {} {} {} {LY} Benzohydrazide {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Benzohydrazide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Benzohydrazide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Benzohydrazide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Benzohydrazide {} {} {} {} {}
PubChem Substance ID87563338
EC Number210-363-9
Beilstein Registry Number9,319
Reaxys-RN471797
Chemical Name Translation苯甲酰肼
Wiswesser Line NotationZMR XVQ
LabNetwork Molecule IDLN00160179
InChIInChI=1S/C7H8N2O/c8-9-7(10)6-4-2-1-3-5-6/h1-5H,8H2,(H,9,10)
Canonical SMILESO=C(NN)C1=CC=CC=C1
GHS Symbol
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 15 gm/kg/77W-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
   Blood - lymphoma, including Hodgkin's disease
REFERENCE :
   EJCAAH European Journal of Cancer.  (Oxford, UK)  V.1-17(6), 1965-1981. For
   publisher information, see EJCODS.  Volume(issue)/page/year: 8,341,1972

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 13 gm/kg/30W-I
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
REFERENCE :
   34ZRA9 "Proceedings of the Quadrennial Conference on Cancer, 3rd, 1965,"
   Severi, L., ed., Perugia, Italy, Univ. of Perugia, 1966
   Volume(issue)/page/year: -,869,1965

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 122 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 122,110,1958

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 102 mg/kg
TOXIC EFFECTS :
   Endocrine - hypoglycemia
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 30,87,1927

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - somnolence (general depressed activity)
   Behavioral - tremor
REFERENCE :
   BJPCAL British Journal of Pharmacology and Chemotherapy.  (London, UK)
   V.1-33, 1946-68.  For publisher information, see BJPCBM.
   Volume(issue)/page/year: 11,417,1956

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 122 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   YKKZAJ Yakugaku Zasshi.  Journal of Pharmacy.  (Nippon Yakugakkai, 2-12-15
   Shibuya, Shibuya-ku, Tokyo 150, Japan)  No.1-    1881-
   Volume(issue)/page/year: 81,1225,1961

Warnings IRRITANT
WGK Germany3
Hazard statements
  • H301 Toxic if swallowed 吞食有毒
  • H302 Harmful if swallowed 吞食有害
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
    Personal Protective Equipment Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
    Hazard Codes 6.1 T
    RTECSDH1575000
    Precautionary statements
    • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
    • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
    • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
    • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
    • P301+P310
    • P301+P312+P330
    • P302+P352+P332+P313+P362+P364
    • P305+P351+P338
    • P305+P351+P338+P337+P313
    • P332+P313
    • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
    • P501 Dispose of contents/container to..… 处理内容物/容器.....
      Signal word Danger
      Safety Statements
      • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
      • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
      • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
        Risk Statements
        • R25 Toxic if swallowed 吞咽有毒
        • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
        • R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
          UN Number 2811 UN 2811 6.1/PG 3
          Storage condition Store at room temperature {LY} Store at room temperature {} {LY} Store at room temperature {} {} {LY} Store at room temperature {} {} {} {LY} Store at room temperature {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
          Packing GroupIII
        • 有机合成。
        • {uni_hamburg} Short: III/35E
        • {TRC} Bolann, B., et al.: Bio. Chem. J., 243, 55 (1987),
        • {uni_hamburg} Short: III/20a
        • {TRC} Metwally, K., et al.: Bio. Med. Chem., 14, 8675 (2006),
        • {ALF} Reacts with aldehydes to form benzoylhydrazones. These have been reported as useful, stable surrogates of unstable imines in allylation, Mannich-type and cyanide addition reactions: J. Org. Chem., 64, 8054 (1999).
        • {ALF} Hydrazides can be reduced to aldehydes with NaBH4 in the presence of CuCl2. For benzhydrazide, an 82% yield was reported: Org. Prep. Proced. Int., 20, 405 (1988).
        • {ALD} Beilstein:9,319
        • {TRC} Mishra, L., et al.: Bio. Med. Chem., 3, 1241 (1995),
          • 613-94-5 H82899 Benzhydrazide 苯甲酰肼

          化学属性

          Mol. FormulaC7H8N2O
          Mol. Weight136.15
          Melting Point112-114°C
          TSCAYes
          Density1.164
          Stability对湿度敏感
          Boiling Point250.42 °C at 760 mmHg
          Appearance 白色至微黄色结晶。

          *以上化合物性质及应用等信息仅供参考