1.3-二酮系列产品
杂环化合物是有机化合物中数量最庞大的一个类别,约占总数的三分之二以上,是多种化学类药物的合成砌块,除此杂环化合物之外还应用于纳米材料、超导材料、农用化学品等的合成。而1, 3-二酮类化合物作为杂环化合物一类重要的合成子, 它的α位活泼亚甲基可通过手性催化剂、金属催化剂或廉价易得的碱,催化形成新的碳-碳键、碳-杂键等,从而高效合成一系列杂环化合物。例如:1,3-二酮化合物经过一系列串联反应,合成吡唑羧酸类杂环化合物[1],这类分子具有KEAP1抑制活性,可以破坏NRF2和KEAP1蛋白之间相互作用,治疗慢性氧化应激疾病。
(a) DMF-DMA, TsOH, 130 °C, 15 min microwave;(b) 2-bromopyridine-6-hydrazine or 3-bromophenyl hydrazine, DIPEA, EtOH;
(c) 3-bromo-N,N-dimethylbenzamide, Pd(PPh3)4, Na2CO3, dioxane/H2O, 100 °C, 1 h then NaOH or LiOH.
图一 Journal of Medicinal Chemistry, 2021, 64 , 15949-15972.
研峰科技拥有完整配套的研发生产设备,通过前期大量的工艺研究、公司规范有效的管控流程及智能管理系统,实现了1.3-二酮系列产品稳定量产,质量稳定,满足客户要求,还可以根据客户的需要进行定制。详细产品情况请致电客服人员(400-106-2016)进行咨询。
Chemical Name | Ethyl 2,4-dioxopentanoate |
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CAS Number | 615-79-2 |
Alfabeta Name | ETHYLDIOXOPENTANOATE 24-, |
MDL Number | MFCD00009124 |
Synonym | Ethyl 2,4-dioxovalerate {LY} Ethyl 2,4-dioxovalerate {} {LY} Ethyl 2,4-dioxovalerate {} {} {LY} Ethyl 2,4-dioxovalerate {} {} {} {LY} Ethyl 2,4-dioxovalerate {} {} {} {} {LY} Ethyl 2,4-dioxovalerate {} {} {} {} {} {LY} Ethyl 2,4-dioxovalerate {} {} {} {} {} {} {LY} Ethyl 2,4-dioxovalerate {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Ethyl 2,4-dioxovalerate {} {} {} {} {} {} {} {} {LY} Ethyl 2,4-dioxovalerate {} {} {} {} {} {} {} {} {} {LY} Ethyl 2,4-dioxovalerate {} {} {} {} {} {} {} {} {} {} {LY} Ethyl 2,4-dioxovalerate {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {LY} Ethyl 2,4-dioxovalerate {} {} {} {} {} {} {} {} {} {} {} {} {LY} Ethyl 2,4-dioxovalerate {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Ethyl 2,4-dioxovalerate {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Ethyl 2,4-dioxovalerate {} {} {} {} {} {} {} {} {} |
Beilstein Registry Number | 607062 |
PubChem Substance ID | 69208 |
EC Number | 210-447-5 |
Chemical Name Translation | 乙酰丙酮酸乙酯 |
InChIKey | OYQVQWIASIXXRT-UHFFFAOYSA-N |
LabNetwork Molecule ID | LN00009536 |
Reaxys-RN | 607062 |
InChI | InChI=1S/C7H10O4/c1-3-11-7(10)6(9)4-5(2)8/h3-4H2,1-2H3 |
Canonical SMILES | CC(CC(C(OCC)=O)=O)=O |
Warnings | IRRITANT |
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WGK Germany | 3 |
Personal Protective Equipment | Eyeshields, Gloves |
Safety Statements | |
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Storage condition | Store at room temperature {LY} Store at room temperature {} {LY} Store at room temperature {} {} {LY} Store at room temperature {} {} {} {LY} Store at room temperature {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} |
Precautionary statements | |
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Restrict | - |
*以上化合物性质及应用等信息仅供参考