研峰科技 Infinity Scientific

2-Amino-1,3,4-thiadiazole 2-氨基-1,3,4-噻二唑

规格: 98%

CAS: 4005-51-0

产品编号: H84906

MDL: MFCD00003107

品牌: INFI

Chemical Name	2-氨基-1,3,4-噻二唑
CAS Number	4005-51-0
Alfabeta Name	THIADIAZOLYLAMINE 1342[]--,,
MDL Number	MFCD00003107
Synonym	1,3,4-Thiadiazol-2-amine {LY} 1,3,4-Thiadiazol-2-amine {} {LY} 1,3,4-Thiadiazol-2-amine {} {} {LY} 1,3,4-Thiadiazol-2-amine {} {} {} {LY} 1,3,4-Thiadiazol-2-amine {} {} {} {} {LY} 1,3,4-Thiadiazol-2-amine {} {} {} {} {} {LY} 1,3,4-Thiadiazol-2-amine {} {} {} {} {} {} {LY} 1,3,4-Thiadiazol-2-amine {} {} {} {} {} {} {} {LY} 1,3,4-Thiadiazol-2-amine {} {} {} {} {} {} {} {} {LY} 1,3,4-Thiadiazol-2-amine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 1,3,4-Thiadiazol-2-amine {} {} {} {} {} {} {} {} {} {} {LY} 1,3,4-Thiadiazol-2-amine {} {} {} {} {} {} {} {} {} {} {} {LY} 1,3,4-Thiadiazol-2-amine {} {} {} {} {} {} {} {} {} {} {} {} {LY} 1,3,4-Thiadiazol-2-amine {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 1,3,4-Thiadiazol-2-amine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 1,3,4-Thiadiazol-2-amine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 1,3,4-Thiadiazol-2-amine {} {} {} {} {} {} {} {} {} {} {} {} {} {
EC Number	223-657-7
Beilstein Registry Number	107135
PubChem Substance ID	19909
Reaxys-RN	107135
Chemical Name Translation	2-氨基-1,3,4-噻二唑
Wiswesser Line Notation	T5NN DSJ CZ
LabNetwork Molecule ID	LN00119552
InChI	InChI=1S/C2H3N3S/c3-2-5-4-1-6-2/h1H,(H2,3,5)
Canonical SMILES	NC1=NN=CS1

GHS Symbol

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 200 mg/kg
TOXIC EFFECTS :
   Behavioral - muscle weakness
   Gastrointestinal - hypermotility, diarrhea
   Skin and Appendages - hair
REFERENCE :
   TAKHAA Takeda Kenkyusho Ho.  Journal of the Takeda Research Laboratories.
   (Takeda Yakuhin Kogyo K.K., 2-17-85 Jusohon-machi, Yodogawa-ku, Osaka 532,
   Japan)  V.29-    1970-  Volume(issue)/page/year: 35,68,1976

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JHMJAX Johns Hopkins Medical Journal.  (Baltimore, MD)  V.120-151, 1967-82.
   Discontinued.  Volume(issue)/page/year: 130,95,1972

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 6500 mg/kg
TOXIC EFFECTS :
   Behavioral - muscle weakness
   Gastrointestinal - hypermotility, diarrhea
   Skin and Appendages - hair
REFERENCE :
   TAKHAA Takeda Kenkyusho Ho.  Journal of the Takeda Research Laboratories.
   (Takeda Yakuhin Kogyo K.K., 2-17-85 Jusohon-machi, Yodogawa-ku, Osaka 532,
   Japan)  V.29-    1970-  Volume(issue)/page/year: 35,68,1976

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1600 mg/kg
SEX/DURATION            : female 1-16 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   TJADAB Teratology, The International Journal of Abnormal Development. (Alan
   R. Liss, Inc., 41 E. 11th St., New York, NY 10003)  V.1-    1968-
   Volume(issue)/page/year: 5,250,1972

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 20 mg/kg
SEX/DURATION            : female 10 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
   before birth)
REFERENCE :
   YHHPAL Yaoxue Xuebao.  Acta Pharmaceutica Sinica.  Pharmaceutical Journal.
   (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep.
   China)  V.1-    1953-    Suspen

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 20 mg/kg
SEX/DURATION            : female 10 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
   CPHPA5 Jiepou Xuebao.  Journal of Anatomy.  (China International Book
   Trading Corp., POB 2820, Beijing, Peop. Rep. China)  V.1-9, 1953-66; V.10-
   1979-  Volume(issue)/page/year: 12,212,1981

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF E

Warnings	IRRITANT
Signal word	Warning
WGK Germany	3
Safety Statements
S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见； S36 Wear suitable protective clothing 穿戴适当的防护服； S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套； S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
Risk Statements
R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害 R22 Harmful if swallowed 吞咽有害 R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性 R63 Possible risk of harm to the unborn child 可能危害未出生婴儿 R68 Possible risk of irreversible effects 可能有不可挽回的作用的危险
Precautionary statements
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。 P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。 P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。 P301+P310+P330 P305+P351+P338 P332+P313 P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用 P405 Store locked up. 上锁保管。 P501 Dispose of contents/container to..… 处理内容物/容器.....
RTECS	XI3000000
Packing Group	III
UN Number	2811
Hazard statements
H315 Causes skin irritation 会刺激皮肤 H335 May cause respiratory irritation 可能导致呼吸道刺激 H302 Harmful if swallowed 吞食有害 H319 Causes serious eye irritation 严重刺激眼睛 H301 Toxic if swallowed 吞食有毒
Personal Protective Equipment	dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes	6.1 Xn Xn,Xi
Hazard Class	6.1
Storage condition	2-8°C, protect from light {LY} 2-8°C, protect from light {} {LY} 2-8°C, protect from light {} {} {LY} 2-8°C, protect from light {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}

A thiadiazole derivative with fungacidal properties. An antitumor agent.

{TRC} Lu, K. et al.: Cancer Chemother. Pharmacol., 4, 275 (1980); Rauckyte, T. et al.: ECOpole?04, Ksiega Konf./Proc., 139 (2004); Nelson, J.A. et al.: Cancer Res., 36, 1375 (1976);

4005-51-0 H84906 2-Amino-1,3,4-thiadiazole
2-氨基-1,3,4-噻二唑

化学属性

Mol. Formula	C2H3N3S
Mol. Weight	101.13
Density	1.422
Melting Point	181-182°C
TSCA	No
Appearance	白色结晶。熔点:190-192℃。
Boiling Point	238.9°C at 760 mmHg

*以上化合物性质及应用等信息仅供参考