Aprepitant 阿瑞匹坦

规格: 95%
CAS: 170729-80-3
产品编号: H85915
MDL: MFCD08277635
品牌: INFI
Chemical Name5-[2(R)-[1(R)-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3(S)-(4-fluorophenyl)morpholin-4-ylmethyl]-3,4-dihydro-2H-1,2,4-triazol-3-one
CAS Number170729-80-3
Synonym 5-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-3H-1,2,4-triazol-3-one Emend L 754030 MK 0869 MK 869 ONO 7436
Chemical Name Translation5-[2(R)-[1(R)-[3,5-二(三氟甲基)苯基]乙氧基]-3(S)-(4-氟苯基)吗啉-4-基甲基]-3,4-二氢-2H-1,2,4-三唑-3-酮
MDL NumberMFCD08277635
Reaxys-RN8096869
Merck Number753
PubChem Substance ID354334991
GHS Symbol
Hazard statements
  • H319 Causes serious eye irritation 严重刺激眼睛
    RTECSXZ5480400
    Signal word
    Precautionary statements
    • P201 Obtain special instructions before use. 使用前获取专门指示。
    • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前,切勿操作。
    • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
    • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
    • P305+P351+P338+P337+P313
    • P308+P313
    • P405 Store locked up. 上锁保管。
    • P501 Dispose of contents/container to..… 处理内容物/容器.....
      Storage condition 0-10°C
    • ########
    • {MCE} [2]. Bayati S, et al. Inhibition of tachykinin NK1 receptor using aprepitant induces apoptotic cell death and G1 arrest through Akt/p53 axis in pre-B acute lymphoblastic leukemia cells. Eur J Pharmacol. 2016 Nov 15;791:274-283.
    • {MCE} [3]. Mannangatti P, et al. Differential effects of aprepitant, a clinically used neurokinin-1 receptor antagonist on the expression of conditioned psychostimulant versus opioid reward. Psychopharmacology (Berl). 2017 Feb;234(4):695-705.
    • {MCE} [4]. Barrett JS, et al. Pharmacologic rationale for the NK1R antagonist, aprepitant as adjunctive therapy in HIV. J Transl Med. 2016 May 26;14(1):148.
    • {TRC} Campos, D., et al.: J. Clin. Oncol., 19, 1759 (2001),
    • {TRC} Hale, J.J., et al.: J. Med. Chem., 41, 4607 (1998),
    • {TRC} Van Belle, S., et al.: Cancer, 94, 3032 (2002),
    • {MCE} [1]. Martinez AN, et al. Aprepitant limits in vivo neuroinflammatory responses in a rhesus model of Lyme neuroborreliosis. J Neuroinflammation. 2017 Feb 15;14(1):37.
    • {MCE}
    • 170729-80-3 H85915 Aprepitant
阿瑞匹坦

      化学属性

      Mol. FormulaC23H21F7N4O3
      Mol. Weight534
      Melting Point250.0 to 255.0 deg-C
      Density1.0

      *以上化合物性质及应用等信息仅供参考