1,2,4-1H-Triazole 1,2,4-三氮唑

规格: 99%
CAS: 288-88-0
产品编号: H89755
MDL: MFCD00005228
品牌: INFI
Chemical Name1,2,4-Triazole
CAS Number288-88-0
PubChem Substance ID9257
EC Number206-022-9
Beilstein Registry Number104767
MDL NumberMFCD00005228
Reaxys-RN104767
Merck Number9605
Synonym 1,2,4-Triazole {LY} 1,2,4-Triazole {} {LY} 1,2,4-Triazole {} {} {LY} 1,2,4-Triazole {} {} {} {LY} 1,2,4-Triazole {} {} {} {} {LY} 1,2,4-Triazole {} {} {} {} {} {LY} 1,2,4-Triazole {} {} {} {} {} {} {LY} 1,2,4-Triazole {} {} {} {} {} {} {} {LY} 1,2,4-Triazole {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 1,2,4-Triazole {} {} {} {} {} {} {} {} {} {LY} 1,2,4-Triazole {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 1,2,4-Triazole {} {} {} {} {} {} {} {} {} {} {} {LY} 1,2,4-Triazole {} {} {} {} {} {} {} {} {} {} {} {} {LY} 1,2,4-Triazole {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 1,2,4-Triazole {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 1,2,4-Triazole {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 1,2,4-Triazole {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 1,2,4-Triazole {} {} {} {} {}
Chemical Name Translation1,2,4-三氮唑
LabNetwork Molecule IDLN00199592
InChIInChI=1S/C2H3N3/c1-3-2-5-4-1/h1-2H,(H,3,4,5)
Canonical SMILESN1N=CN=C1
GHS Symbol
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1750 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - excitement
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 51(11),65,1986

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Bird - quail
DOSE/DURATION           : >316 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   EESADV Ecotoxicology and Environmental Safety.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802)  V.1-    1977-  Volume(issue)/page/year:
   6,149,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1350 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - excitement
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 51(11),65,1986

WGK Germany2
Hazard Codes Xn Xn,Xi
Hazard statements
  • H302 Harmful if swallowed 吞食有害
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H361 Suspected of damaging fertility or the unborn child 怀疑对生育能力或未出生婴儿造成伤害
  • H361d Suspected of damaging the unborn child 怀疑对未出生婴儿造成伤害
    Personal Protective Equipment Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
    RTECSXZ3806000
    Precautionary statements
    • P201 Obtain special instructions before use. 使用前获取专门指示。
    • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
    • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
    • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
    • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
    • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
    • P281 Use personal protective equipment as required. 使用所需的个人防护装备。
    • P301+P312
    • P301+P312+P330
    • P305+P351+P338
    • P305+P351+P338+P337+P313
    • P308+P313
    • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
    • P330 Rinse mouth. 漱口
    • P332+P313
    • P337+P313
    • P405 Store locked up. 上锁保管。
    • P501 Dispose of contents/container to..… 处理内容物/容器.....
      Signal word Warning
      Safety Statements
      • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
        Risk Statements
        • R22 Harmful if swallowed 吞咽有害
        • R36 Irritating to eyes 刺激眼睛
        • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
        • R63 Possible risk of harm to the unborn child 可能危害未出生婴儿
          Storage condition Store at room temperature {LY} Store at room temperature {} {LY} Store at room temperature {} {} {LY} Store at room temperature {} {} {} {LY} Store at room temperature {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room te
        • 该品用于农药；医药（氟康唑）；染料；橡胶助剂的生产，也用于复制系统的光电导体。
        • {ALFA} Bifunctional acylation catalyst, often superior to Imidazole, A10221, for esterification, amidation, etc. Has found limited use as a catalyst for low-racemization peptide bond formation: Proc. Chem. Soc., 266 (1963); Rec. Trav. Chim., 84, 213 (1965); Liebigs Ann. Chem., 691, 212 (1966). See Appendix 6.
        • {ALF} Bifunctional acylation catalyst, often superior to Imidazole, A10221, for esterification, amidation, etc. Has found limited use as a catalyst for low-racemization peptide bond formation: Proc. Chem. Soc., 266 (1963); Rec. Trav. Chim., 84, 213 (1965); Liebigs Ann. Chem., 691, 212 (1966). See Appendix 6.
        • {ALFA} 41, 1297 (2000).
        • {ALD} Merck: 14,9605
        • {ALF} In a comparative study of 1- vs 4-alkylation using different bases it was found that the best yields of the 1-substituted regioisomers were obtained with DBU: Tetrahedron Lett.,
        • {ALF} 41, 1297 (2000).
        • {ALD} Merck: 14,9605
        • Beilstein:26,13
        • {ALFA} In a comparative study of 1- vs 4-alkylation using different bases it was found that the best yields of the 1-substituted regioisomers were obtained with DBU: Tetrahedron Lett.,
          • 288-88-0 H89755 1,2,4-1H-Triazole 1,2,4-三氮唑

          化学属性

          Mol. FormulaC2H3N3
          Mol. Weight69.07
          Boiling Point260°C at 760 mmHg
          Melting Point115-117°C
          Flash Point170°C
          TSCAYes
          Solubility1250 G/L (20 ºC)
          Density1.274
          Appearance 1，2，4-三唑纯品为白色针状晶体，工业品为粉红色或褐色固体，m.p.120～121℃，分解点220℃以上，易溶于水，微溶于丙酮、乙酸乙酯，不溶于氯仿、苯。
          Stability对光线敏感
          pH:A

          *以上化合物性质及应用等信息仅供参考