| Chemical Name | Trifluoroacetic anhydride |
|---|
| Synonym |
2,2,2-Trifluoroacetic anhydride
2,2,2-Trifluoroacetic anhydride; TFAA
Acetic acid, trifluoro-, anhydride
Aceticacid,trifluoro-,anhydride
Anhydrid kyseliny trifluoroctove
BIS(TRIFLUOROACETIC) ANHYDRIDE
Bis(trifluoracet)-anhydrid
Bis(trifluoroacetic) anhydride
Hexafluoroacetic anhydride
Perfluoroacetic anhydride
TFA
TFAA
TFAA Trifluoroacetic anhydride (TFAA) acetic anhydride boron trifluoride butanol hexafluoroisopropanol trifluoroacetic acid trimethylamine (TMA)
TRIFLUORACETIC ANHYDRIDE
TRIFLUOROACETIC ACID ANHYDRIDE
TRIFLUOROACETIC ANHYDRIDE
TRIFLUOROACETIC ANHYDRIDE, REAGENTPLUS, >=99%
Trifluoressigsäure-Anhydrid
Trifluoressigsäureanhydrid
Trifluoroacetic acid anhydride
{P |
| PubChem Substance ID | 9845 |
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| EC Number | 206-982-9 |
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| Beilstein Registry Number | 746197 |
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| Reaxys-RN | 746197 |
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| Chemical Name Translation | 三氟乙酸酐 |
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| Wiswesser Line Notation | FXFFVOVXFFF |
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| LabNetwork Molecule ID | LN00199052 |
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| InChI | InChI=1S/C4F6O3/c5-3(6,7)1(11)13-2(12)4(8,9)10 |
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| MDL Number | MFCD00000416 |
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| CAS Number | 407-25-0 |
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GHS Symbol
| WGK Germany | 2 |
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| Hazard Codes |
8
C |
| Hazard statements | |
|---|
- H290 May be corrosive to metals 可能腐蚀金属。
- H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
- H332 Harmful if inhaled 吸入有害
- H412 Harmfutoaquaticlifewithlonglastingeffects 对水生生物有害并具有长期影响。
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| Personal Protective Equipment |
Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US) |
| RTECS | AJ9800000 |
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| Precautionary statements | |
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- P234 Keep only in original container. 只保留在原来的容器中。
- P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
- P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
- P273 Avoid release to the environment. 避免释放到环境中。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P301+P330+P331
- P301+P330+P331+P310
- P303+P361+P353
- P303+P361+P353+P310+P363
- P304+P312
- P304+P340
- P304+P340+P310
- P305+P351+P338
- P305+P351+P338+P310
- P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
- P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
- P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
- P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
- P390 Absorb spillage to prevent material damage. 吸收溢出物，防止重大损害。
- P405 Store locked up. 上锁保管。
- P406 Store in corrosive resistant/… container with a resistant inner liner. 存放在耐腐蚀/具有耐性的内衬容器。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
|
| Signal word |
Danger |
| UN Number |
3265
UN3265 |
| Risk Statements | |
|---|
- R14 Reacts violently with water 遇水会猛烈反应
- R20 Harmful by inhalation 吸入有害
- R35 Causes severe burns 会导致严重灼伤
- R52/53
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| Safety Statements | |
|---|
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
- S43 In case of fire use ... (indicate in the space the precise type of fire-fighting equipment. If water increases the risk add -?Never use water) 着火时使用（指明具体的消防器材种类，如果用水增加危险，注明“禁止用水”
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
- S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
|
| Storage condition |
Moisture Sensitive
密封阴凉干燥保存。
2-8°C
密封阴凉干燥保存。储存温度2-8°C |
| Packing Group | I |
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| Hazard Class | 8 |
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| Warnings |
危化品目录(2015) |
| Restrict |
危险品 |
用作分析试剂、溶剂、催化剂、硝化反应促进剂、脱水缩合剂、羟基和氨基三氟乙酰化时的保护剂 ，有机合成。气相色谱分析中生物活性化合物。伯胺、仲胺的保护剂。也用于醛类氧化成酸类、酯类和胺类。
衍生级用于保护伯胺和仲胺。衍生化物更易挥发。
{ALF} For the ɑ-trifluoroacetylation of a phosphonium salt in a route to perfluoroalkyl acetylenes, see: Org. Synth. Coll., 9, 436 (1998). For reaction scheme, see (Ethoxycarbonyl­methyl)­triphenyl­phosphonium bromide, A16347.
{ALFA} In pyridine, de
{ALD} Beilstein:2(2)186
{ALF} Alternative to Oxalyl­ chloride, A18012, for activation of Dimethyl­ sulfoxide, A13280 in th
{ALFA} Mild conversion of aryl halides to aryl trifluoromethyl ketones via Pd catalyzed stannylation: Synlett, 165 (1995).
{ALF} In pyridine, dehydrates carboxamides or aldoximes to nitriles: Tetrahedron Lett., 1813 (1977); Synthesis, 56, (1979). With triethylamine, effects the dehydration of aldols to enones, where other methods are less successful: Org. Synth. Coll., 8, 210 (1993).
{ALFA} In pyridine and dichloromethane or ether, converts acid chlorides to trifluoromethyl ketones in good yields via a trifluoroacyl ketene intermediate: Tetrahedron, 51, 2573 (1995). The method has been extended to the synthesis of a range of trifluoromethylated heterocycles: Tetrahedron, 51, 2585 (1995):
{ALF} Trifluoroacetyl esters are rapidly hydrolyzed at pH 7: Tetrahedron Lett., 1039 (1963). Trifluoroacetamides are also readily hydrolyzed e.g. by mild base; selective cleavage of a trifluoroacetamide can be achieved in the presence of a methyl ester: J. Org. Chem., 54, 2498 (1989). For the racemization-free removal of the N-trifluoroacetyl group from peptides by NaBH4, see: Chem. Ber., 103, 2437 (1970).
{ALFA} Trifluoroacetylating agent for protection of alcohols and amines: Helv. Chim. Acta., 37, 443 (1954); Tetrahedron, 43, 5583 (1987); Tetrahedron Lett., 28, 4737 (1987), useful, e.g. as volatile derivatives in GC: J. Chromat., 43, 129 (1969); 61, 225 (1971); 93, 223, 447 (1974); D. R. Knapp, Handbook of Analytical Derivatisation Reactions, Wiley, N.Y. (1979); Handbook of Derivatives for Chromatography, 2nd ed., K. Blau and J. M. Halket, Eds., Wiley, Chichester (1993).
