Oxalyl chloride 草酰氯

规格: 98%
CAS: 79-37-8
产品编号: H98809
MDL: MFCD00000704
品牌: INFI
Chemical NameOxalyl Chloride
Synonym Oxalyl Chloride {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {
CAS Number79-37-8
EC Number201-200-2
Beilstein Registry Number2,542
MDL NumberMFCD00000704
PubChem Substance ID87574093
Merck Number6914
Reaxys-RN1361988
Chemical Name Translation草酰氯
LabNetwork Molecule IDLN00163171
InChIInChI=1S/C2Cl2O2/c3-1(5)2(4)6
Canonical SMILESClC(=O)C(=O)Cl
GHS Symbol
TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1840 ppm/1H
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - corneal damage
   Lungs, Thorax, or Respiration - dyspnea
   Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
   AIHAAP American Industrial Hygiene Association Journal.  (AIHA, 475 Wolf
   Ledges Pkwy., Akron, OH 44311)  V.19-    1958-  Volume(issue)/page/year:
   56,74,1995

Signal word
WGK Germany2
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
  • S20 When using do not eat or drink 使用时，不得进食，饮水；
  • S7/8 Keep container tightly closed and dry 保存在严格密闭容器中，保持干燥；
  • S23 Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer) 不要吸入气体/烟雾/蒸汽/喷雾；
  • S30 Never add water to this product 切勿将水加入该产品中；
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S4 Keep away from living quarters 远离生活区；
  • S9 Keep container in a well-ventilated place 保持容器在通风良好的场所；
  • S8 Keep container dry 保持容器干燥；
    Risk Statements
    • R34 Causes burns 会导致灼伤
    • R20 Harmful by inhalation 吸入有害
    • R14 Reacts violently with water 遇水会猛烈反应
    • R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
    • R29 Contact with water liberates toxic gas. 遇水释放出有毒气体
    • R37 Irritating to respiratory system 刺激呼吸道
    • R23 Toxic by inhalation 吸入有毒
    • R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入，皮肤接触及吞食都有毒
      Precautionary statements
      • P303+P361+P353+P310+P363
      • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
      • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
      • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
      • P305+P351+P338
      • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
      • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
      • P403+P233
      • P301+P330+P331
      • P501 Dispose of contents/container to..… 处理内容物/容器.....
      • P405 Store locked up. 上锁保管。
      • P303+P361+P353
      • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
      • P304+P340+P311
      • P304+P340+P310
      • P305+P351+P338+P310
      • P301+P330+P331+P310
        Hazard statements
        • H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
        • H331 Toxic if inhaled 吸入中毒
        • H335 May cause respiratory irritation 可能导致呼吸道刺激
        • H332 Harmful if inhaled 吸入有害
        • H336 May cause drowsiness or dizziness 肯能导致嗜睡或头晕
        • H351 Suspected of causing cancer 怀疑致癌
        • H373 May causes damage to organs through prolonged or repeated exposure 长期或频繁接触可能会损伤器官
          Personal Protective Equipment Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US) Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
          RTECSKI2950000
          Packing GroupII
          UN Number 2922
          Storage condition +4°C +4℃ 2-8°C 4 4℃ Store Cold {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
          Hazard Codes T C,T
          Hazard Class8/6.1
          Warnings 危化品目录(2015)
          Restrict 危险品
        • 分析试剂。主要用于磺酰脲类除草剂、杀虫剂、医药化学合成的重要原料中间体，也是聚酰胺、化学冷光剂、液晶等化学工业的优质酰化剂等领域,有机合成的加氯剂。
        • {ALF} Caution! Carbon monoxide may be evolved.
        • {ALF} For a brief feature on uses of this reagent in Organic synthesis, see: Synlett, 1172 (2007).
        • {ALF} Friedel-Crafts reaction with arenes give carboxylic acids via the acid chlorides; see, e.g.: Org. Synth. Coll., 5, 706 (1973); 7, 420 (1990). For other phosgene equivalents, see Trichloromethyl­ chloroformate, A17444, and Triphosgene, A14932.
        • {ALF} Has advantages over POCl3 in the Vilsmeier formylation reaction in that cleaner reactions often occur and a much lower mass of acidic by-product is formed. See N,N-Dimethyl­formamide, A13547 and (Chloromethyl­ene)­dimethyl­ammonium chloride, B24172.
        • {ALD} Merck: 14,6914
        • {ALD} Merck: 14,6914
        • Beilstein:2,542
        • {ALF} Mild reagent for conversion of sensitive acids to acid chlorides; see, e.g.: Org. Synth. Coll., 8, 486 (1993); Org. Synth. Coll., 9, 516 (1998).
        • {ALF} Reaction with Grignards in the presence of LiBr and CuBr provides a route to symmetrical ɑ-diones in good yield: Tetrahedron Lett., 36, 7305 (1995).
        • {ALF} Reactive acid chloride which can be used as a phosgene substitute in many reactions.
        • {uni_hamburg} Short: II/25B
        • {uni_hamburg} Short: III/20a
        • {uni_hamburg} Short: III/31a
        • {ALF} Widely used to activate Dimethyl­ sulfoxide, A13280, for selective oxidation of alcohols to aldehydes or ketones (Swern oxidation) at low temperatures under very mild conditions: J. Org. Chem., 43, 2480 (1978). The reactive species is thought to be chlorodimethylsulfonium chloride: J. Org. Chem., 44, 4148 (1979). For examples of Swern oxidations, see: Org. Synth. Coll., 7, 258 (1990); 8, 501 (1993); 9, 692 (1998); Org. Synth., 76, 110 (1998). See also Trifluoroacetic anhydride, A13614.
          • 79-37-8 H98809 Oxalyl chloride 草酰氯

          化学属性

          Mol. FormulaC2Cl2O2
          Mol. Weight126.93
          Density1.335
          Refractive index1.4280 to 1.4320
          Vapor Density4.4 (vs air)
          Boiling Point62 - 65 °C(lit.)
          Vapor Pressure150 mmHg ( 20 °C)
          Melting Point−10 - −8 °C(lit.)
          TSCAYes
          Solubility起反应
          Stability对湿度敏感
          Flash Point176-178°C
          pH:A

          *以上化合物性质及应用等信息仅供参考