包装 价格 库存 - 促销价
100mg    RMB   290
500mg    RMB   980
1g       RMB  1530
Digitonin	毛地黄皂苷

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毛地黄皂苷,从紫花毛地黄的叶和种子中得到的一种配糖体。甾体皂角苷的一种,水解时,可生成作为糖苷配基(aglycone)部分的一分子毛地黄皂苷配基(digitogenin),而作为糖的部分有2分子的D-葡萄糖和2分子一半乳糖以及1分子的木糖。这些糖部分是结合到毛地黄皂苷配基的第三碳原子的羟基上。因为它能和具有游离3β-OH的甾体类(例如胆甾醇)以等分子的比例形成难溶于水的分子化合物的毛地黄皂苷化合物(digitonide),因此,这种特性被利用来进行甾醇的定性和分离。

产品应用

应用一:植物蛋白提取时,作为蛋白增溶剂使用。
应用二:毛地黄皂苷敏感性试验,可进行微生物分型、脂类代谢研究。
应用三:血脂测定、胆固醇测定。
应用四:与细胞膜上的胆固醇作用使细胞膜穿孔,作进一步细胞内外研究。

SPC品牌毛地黄皂苷

中文名称:毛地黄皂苷 
中文别名:洋地黄皂苷 
英文名称:Digitonin 
Cas No.:11024-24-1 
产地:北京 
包装:1g 
库存:现货 
含量:50% 
熔点:230-240℃ 
外观:白色晶体或粉末 
分子式:C56H92O29 
分子量:1229.33 
产品实拍图片:
中文备注:微溶于水,可溶于酒精。在生化研究中可作为去垢剂和脱溶剂处理分离的线粒体,溶解线粒体外膜。利用沉淀反应测定血浆、胆汁和组织中的胆甾醇。 

SPC品牌毛地黄皂苷实测谱图

  • Mol. Formula: C56H92O29
  • Mol. Weight: 1229.32
  • Melting Point: 230-240 °C (dec.)(lit.)
  • Density: 1.59
Chemical NameDigitonin
Synonym
  • Digitin
  • Digitonin
  • 毛地黃皂苷
  • 毛地黄皂甙,洋地黄皂甙
  • 毛地黄皂苷
CAS Number11024-24-1
PubChem Substance ID 87567200
EC Number234-255-6
Beilstein Registry Number19(3/4)1243
MDL NumberMFCD00077729
Reaxys-RN78654
Merck Number3161
Chemical Name Translation毛地黄皂苷
GHS Symbol
WGK Germany3
Hazard Codes
  • T
Hazard statements
  • H301+311+331
  • H330 Fatal if inhaled 吸入致命
  • H311 Toxic in contact with skin 皮肤接触中毒
  • H301 Toxic if swallowed 吞食有毒
Personal Protective Equipment
  • Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
RTECSIH2050050
Precautionary statements
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+310+330
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P261305+351+338
  • P403+233 Store in a well-ventilated place. Keep container tightly closed. 存放在通风良好的地方。保持容器密闭。
  • P302+352+312+361+364
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适,呼叫解毒中心或医生/医师。
  • P405 Store locked up. 上锁保管。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P304+340+311
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word
UN Number
  • 2811
Safety Statements
  • S22 Do not breathe dust 不要吸入粉尘;
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
  • S28 After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 皮肤接触后,立即用大量…(由生产厂家指定)冲洗;
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
Risk Statements
  • R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入,皮肤接触及吞食都有毒
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Packing GroupIII
Hazard Class6.1
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 90 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig,
   Ger. Dem. Rep.)  Volume(issue)/page/year: 4,1289,1935

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig,
   Ger. Dem. Rep.)  Volume(issue)/page/year: 4,1289,1935

TYPE OF TEST            : LD10 - Lethal Dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 20 mg/kg
TOXIC EFFECTS :
   Tumorigenic - active as anti-cancer agent
REFERENCE :
   PCJOAU Pharmaceutical Chemistry Journal (English Translation).  Translation
   of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013)  No.1-
   1967-  Volume(issue)/page/year: 11,749,1977

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 4 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 12,815,1962

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >50 mg/kg
TOXIC EFFECTS :

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TYPE OF TEST            : Sex chromosome loss and nondisjunction
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 250 ppb
REFERENCE :
   ANYAA9 Annals of the New York Academy of Sciences.  (New York Academy of
   Sciences, 2 E. 63rd St., New York, NY 10021)  V.1-    1877-
   Volume(issue)/page/year: 407,186,1983

  • ⑴. 可燃, 火场排出辛辣刺激烟雾。 ⑵. 利用沉淀反应测定血浆、胆汁和组织中的胆甾醇。 ⑶. 用作较高级醇类和酚类、硫酚类的试剂。 ⑷. 在生化研究中可作为去垢剂和脱溶剂处理分离的线粒体,溶解线粒体外膜。
  • 利用沉淀反应测定血浆、胆汁核组织的胆甾醇。也用作较高级醇类核酚类、硫酚类的试剂。
  • Merck: 14,3161 Beilstein:19(3/4)1243
  • Merck 14 ,3161
  • Prehm, S., et al., A mild purification method for polysaccharide binding membrane proteins: phase separation of digitonin extracts to isolate the hyaluronate synthase from Streptococcus sp. in active form. Protein Expr. Purif. 7 , 343-346, (1996) 摘要
  • Liu, J., et al., Use of digitonin-permeabilized cells in studies of steroid receptor subnuclear trafficking. Methods 19 , 403, (1999) 摘要
  • Nock, B., Extracti-Gel D chromatography is a simple efficient method for removing digitonin during receptor purification: application to the κ 1 opioid receptor. J. Neurosci. Methods 50 , 353, (1993) 摘要
  • 部分产品数据参考 LabNovo , 请谨慎使用并以实际实验测量值为准。