| Chemical Name | Dibutyltin oxide |
|---|
| MDL Number | MFCD00001992 |
|---|
| Synonym |
dbot
Dibutyloxotin
二正丁基氧化锡
dibutylstanniumoxide
Stannane,dibutyloxo-
DIBUTYLTIN OXIDE
二正丁基锡氧化物
dibutyloxideoftin
DIBUTYLTIN(IV) OXIDE
kyslicnikdi-n-butylcinicity
di-n-dibutyltinoxide
Di-n-butyltin oxide
Dibutyloxide of tin
Dibutyloxostannane
氧化二丁基锡
DBOT
氯化二丁基锡
dibutyloxo-ti
DIBUTYLOXOSTANNANE
Tin, dibutyl-, oxide
dbto
Dibutyltin oxide
dibutyloxo-stannan
Dibutylstannium oxide
di-n-butyl-zinn-oxyd
di-n-dibutyltin
二丁基氧化锡
di-n-butylslannicoxide
dibutyltinmonoxide
二丁錫氧
Dibutylstannane oxide
DI-N-BUTYLTIN OXIDE
dibutylstannaneoxide
Di-n-butyl-zinn-oxyd
dibutyl-tioxide
Tin, dibutyloxo-
二丁基氧化錫
DIBUTYLOXOTIN
Kyslicnik di-n-butylcinicity |
| EC Number | 212-449-1 |
|---|
| CAS Number | 818-08-6 |
|---|
| Beilstein Registry Number | 4126243 |
|---|
| PubChem Substance ID | 24851031 |
|---|
| Chemical Name Translation | 二丁基氧化锡 |
|---|
| Wiswesser Line Notation | O-SN-4&4 |
|---|
| LabNetwork Molecule ID | LN01268854 |
|---|
| RTECS | WH7175000 |
|---|
| Safety Statements | |
|---|
- S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
- S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
- S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
- S39 Wear eye/face protection 戴眼睛/面孔保护装置；
- S29 Do not empty into drains 不要排入下水道；
- S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明；
- S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
|
| Packing Group | II |
|---|
| UN Number |
3146
UN 3146 6.1/PG 2
UN3146 |
| Risk Statements | |
|---|
- R25 Toxic if swallowed 吞咽有毒
- R38 Irritating to skin 刺激皮肤
- R48/25
- R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应
- R41 Risk of serious damage to eyes 有严重损伤眼睛的危险
- R60 May impair fertility 可能降低生殖能力
- R61 May cause harm to the unborn child 可能对未出生的婴儿导致伤害
- R68 Possible risk of irreversible effects 可能有不可挽回的作用的危险
- R50/53
- R51/53
- R36 Irritating to eyes 刺激眼睛
|
GHS Symbol
| Precautionary statements | |
|---|
- P273 Avoid release to the environment. 避免释放到环境中。
- P301+P310
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P305+P351+P338
- P201 Obtain special instructions before use. 使用前获取专门指示。
- P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P314 Get medical advice/attention if you feel unwell. 获取医疗咨询/就医，如果你觉得不舒服
|
| Hazard statements | |
|---|
- H372 Causes damage to organs through prolonged or repeated exposure 长期或频繁接触会损伤器官
- H411 Toxictoaquaticlifewithlonglastingeffects 对水生生物有毒性并具有长期影响。
- H318 Causes serious eye damage 严重伤害眼睛
- H300 Fatal if swallowed 吞食致命
|
| WGK Germany | 3 |
|---|
| Personal Protective Equipment |
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges |
| Signal word |
Danger |
| Hazard Codes |
T,N
T |
| Hazard Class | 6.1 |
|---|
| Restrict |
{} {} 剧毒化学品
危险品 |
| Warnings |
危化品目录(2015) |
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 40 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
(usually neuromuscular blockage)
Behavioral - general anesthetic
Behavioral - somnolence (general depressed activity)
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For
publisher information, see FCTOD7. Volume(issue)/page/year: 7,47,1969
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 1500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
SAIGBL Sangyo Igaku. Japanese Journal of Industrial Health. (Nippon Sangyo
Eisei Igakkai, Kosu Eisei Bldg., 1-29-8, Shinjuku, Shinjuku-ku, Tokyo 160,
Japan) V.1- 1959- Volume(issue)/page/year: 15,3,1973
TYPE OF TEST : LD - Lethal dose
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : >2 gm/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes
Kidney, Ureter, Bladder - other changes
Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0570737
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 44900 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie;
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 19916 ug/kg
SEX/DURATION : female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 85,149,1993
{ALF} Reacts with 1,2-diols to form 5-membered cyclic dibutylstannoxane derivatives. For use in the glycoside field, see: Synthesis, 409 (1995). Formation of these derivatives is greatly accelerated by microwave irradiation: Synlett, 89 (1994). The stannylene derivatives are activated to electrophilic attack:
{ALF} With bromine, the ɑ-hydroxy ketone is formed: J. Chem. Soc., Perkin 1, 1568 (1979). With acyl or sulfonyl chlorides, overall regioselective monoacylation of the diol at the more substituted hydroxyl can be achieved: Tetrahedron Lett., 21, 221 (1980); J. Chem. Soc., Chem. Commun., 1457 (1985); J. Org. Chem., 55, 5132 (1990); 61, 5257 (1996). Selective monotosylation of 1,2-diols has also been achieved catalytically: Tetrahedron Lett., 41, 3773 (2000).
{ALF} Catalyst for lactonization and lactamization reactions: J. Am. Chem. Soc., 102, 7578 (1980), particularly useful in the formation of macrolides: J. Am. Chem. Soc., 105, 7130 (1983). For catalysis of N-acylation of hydroxy alcohols with microwave irradiation, see: J. Org. Chem., 61, 5264 (1996).
{ALF} Promotes the cycloaddition of Trimethyl­silyl­ azide, L00173 to nitriles to give 5-aryltetrazoles, some of which are important as angiotensin II inhibitors: J. Org. Chem., 58, 4139 (1993):
{ALF}
{ALF} Catalyst for the dehydration of amides to nitriles under neutral conditions: Synthesis, 1724 (1999); for use of microwave irradiation, see: J. Org. Chem., 64, 1713 (1999).
{ALF} For a brief feature on uses of the reagent in synthesis, see: Synlett, 1847 (2004).
