Chemical Name | 1,4,7,10,13,16-Hexaoxacyclooctadecane (18-Crown-6) |
CAS Number | 17455-13-9 |
Synonym |
18-Crown-6-ether
{LY} 18-Crown-6-ether
{} {LY} 18-Crown-6-ether
{} {} {LY} 18-Crown-6-ether
{} {} {} {LY} 18-Crown-6-ether
{} {} {} {} {LY} 18-Crown-6-ether
{} {} {} {} {} {LY} 18-Crown-6-ether
{} {} {} {} {} {} {LY} 18-Crown-6-ether
{} {} {} {} {} {} {} {LY} 18-Crown-6-ether
{} {} {} {} {} {} {} {} {LY} 18-Crown-6-ether
{} {} {} {} {} {} {} {} {} {LY} 18-Crown-6-ether
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{} {} {} {} {} {} {} {} {} {} {} {LY} 18-Crown-6-ether
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{} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 18-Crown-6-ether
{} {} {} {} {} {} {} {} {} {} {} {} {} {}
{} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 18-Crown-6-ether
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{} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 18-Crown-6-ether
{} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
{} {} {} {} {} {} {} {} {} {} {} |
PubChem Substance ID | 87565919 |
EC Number | 241-473-5 |
Beilstein Registry Number | 1619616 |
MDL Number | MFCD00005113 |
Reaxys-RN | 1619616 |
Merck Number | 2602 |
Chemical Name Translation | 18-冠醚-6 |
Wiswesser Line Notation | T-18-O DO GO JO MO POTJ |
LabNetwork Molecule ID | LN00198526 |
Canonical SMILES | O1CCOCCOCCOCCOCCOCC1 |
GHS Symbol
WGK Germany | 3 |
Hazard Codes |
Xn
Xn,Xi |
Hazard statements | |
- H315 Causes skin irritation 会刺激皮肤
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- H302 Harmful if swallowed 吞食有害
- H319 Causes serious eye irritation 严重刺激眼睛
|
Personal Protective Equipment |
dust mask type N95 (US), Eyeshields, Gloves |
RTECS | MP4500000 |
Precautionary statements | |
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服,清洗后方可重新使用
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P305+P351+P338
- P332+P313
- P305+P351+P338+P337+P313
- P301+P312+P330
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
- P302+P350
|
Signal word |
{} {} {} {} {TCI} |
Storage condition |
2-8°C, sealed storage, away from moisture
{LY} 2-8°C, sealed storage, away from moisture
{} {LY} 2-8°C, sealed storage, away from moisture
{} {} {LY} 2-8°C, sealed storage, away from moisture
{} {} {} {LY} 2-8°C, sealed storage, away from moisture
{} {} {} {} {LY} 2-8°C, sealed storage, away from moisture
{} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture
{} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture
{} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture
{} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture
{} {} {} {} {} {} {} {} {} {LY} Store at room temperature
{} {} {} {} {} {} {} {} {} {}
{} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature
{} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature
{} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature
{} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature
{} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store a |
Safety Statements | |
- S39 Wear eye/face protection 戴眼睛/面孔保护装置;
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
- S36 Wear suitable protective clothing 穿戴适当的防护服;
- S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
|
Risk Statements | |
- R36 Irritating to eyes 刺激眼睛
- R20/22 Harmful by inhalation and if swallowed 吸入和不慎吞咽有害
- R22 Harmful if swallowed 吞咽有害
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
|
Packing Group | III |
Hazard Class | 6.1(b) |
UN Number |
2811 |
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : >1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
RPTOAN Russian Pharmacology and Toxicology (English Translation).
Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey,
UK) V.30- 1967- Volum
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 540 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 53(10),92,1988
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intratracheal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 56 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
Lungs, Thorax, or Respiration - structural or functional change in trachea
or bronchi
Lungs, Thorax, or Respiration - fibrosis, focal (pneumoconiosis)
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0536187
TYPE OF TEST : LD - Lethal dose
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >2500 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
Gastrointestinal - other changes
Liver - other changes
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
大环醚类有机化合物。主要用途为精细有机合成用高效相转移催化剂、络合剂、贵金属和稀土元素分离提取用萃取剂。在化学分析中可用于离子的富集、分离和掩蔽,还可用于医药、生物化学领域以及电子工业中用作离子导电材料、液晶显示元件制作材料。
{ALF} Crown et
{SA} Beil. 19 ,V,12,601
{ALF} Has been widely used in alkylation reactions with, e.g. K2CO3 as base:
{ALF} Has been used with KF to enhance the reactivity of F- as a base or a nucleophile, e.g. to promote Michael additions in aprotic solvents: J. Chem. Soc., Chem. Commun., 237 (1977), the condensation of nitromethane with aldehydes: Tetrahedron Lett., 3219 (1978), and the transesterification of diaryl to dialkyl phosphonates: Synthesis, 409, 412 (1982).
{ALFA} Crown ether catalysis can be used in the reaction of KCN with alkyl halides to give nitriles: Tetrahedron Lett., 71 (1975), and for the preparation of acyl cyanides from acid chlorides: Tetrahedron Lett., 21, 2959 (1980). The 1:1 complex between 18-crown-6 and KCN has been used cata
{ALF} Crown ether (see Appendix 2) mainly used to complex potassium ions. For a comprehensive study of solvent effects on complexation with K ions in a wide range of solvents, see: J. Org. Chem., 61, 5221 (1996).
{ALF} Promotes methylation reactions with Dimethyl­ carbonate, A13104: Synthesis, 382 (1986). N-Alkylation of Glutarimide, L00968, and Succinimide, A13503: Bull. Soc. Chim. Fr., 227 (1992).
{ALF} Crown ether catalysis can be used in the reaction of KCN with alkyl halides to give nitriles: Tetrahedron Lett., 71 (1975), and for the preparation of acyl cyanides from acid chlorides: Tetrahedron Lett., 21, 2959 (1980). The 1:1 complex between 18-crown-6 and KCN has been used catalytically in the cyanosilylation of aldehydes, ketones and quinones with TMSCN; for examples, see: Org. Synth. Coll., 7, 517 (1990).
{ALF} Enables KH to metallate aryl-substituted methanes directly: J. Am. Chem. Soc., 99, 4457 (1977). In the presence of KOH in DME, various arylmethanes, benzyl alcohols and aldehydes are oxidized to carboxylic acids by molecular oxygen: Tetrahedron Lett., 25, 4989 (1984).