4-(Dimethylamino)butanoicacidhydrochloride 4-(二甲胺基)丁酸盐酸盐

规格: 97%
CAS: 69954-66-1
产品编号: H98396
MDL: MFCD00012613
品牌: INFI

mRNA递送载体(脂质纳米粒)合成砌块

2023 年10月2日诺贝尔生理学或医学奖授予美国科学家卡塔林·卡里科(Katalin Karikó)和德鲁·魏斯曼(Drew Weissman)，以表彰他们在核苷碱基修饰方面的发现，开发了针对新冠感染的mRNA(简称核酸)疫苗。mRNA是一个带负电的长链大分子，细胞膜也带有负电，静电排斥作用使mRNA难以进入细胞内，而脂质纳米粒(lipid nanoparticles, LNPs)作为多种治疗剂的常用载体，在有效保护mRNA并将其运输到细胞当中发挥了至关重要的作用。

LNPs是一种多组分系统，通常由阳离子脂质(可电离脂质)、辅助脂质、胆固醇、保护剂聚乙二醇-脂质共轭物组成(如下图所示)，其中阳离子脂质与带负电荷的mRNA结合，将其转变为中性，不仅限制LNPs的毒性，同时促进LNPs中的核酸包封；辅助脂质、胆固醇和聚乙二醇-脂质可以维持粒子的结构并提高稳定性。

国外有“mRNA 疫苗研发三巨头”：Moderna、CureVac、BioNTech，均采用脂质纳米技术递送，这也是目前在核酸药物领域应用比较广泛的递送技术类型。Moderna的SM-102和BioNTech的Acuitas ALC-0315具有一些共同的特征，包括叔胺，支链尾和酯接头，下表根据现有的专利和文献显示了可能的脂质结构。


以上图片均来源于参考文献

研峰科技拥有完整配套的研发生产设备，通过前期大量的工艺研究、公司规范有效的管控流程及智能管理系统，实现了脂质纳米粒中的阳离子脂质合成砌块的稳定量产，质量稳定，满足客户要求，还可以根据客户的需要进行定制。详细产品情况请致电客服人员（400-106-2016）进行咨询。

参考文献：

1. Nat Commun. 2021, 12, 7233.

2. Science. 2022, 376, 6594.




Chemical Name4-(Dimethylamino)butanoicacidhydrochloride
CAS Number69954-66-1
Alfabeta NameDIMETHYLAMINOBUTANOICACIDHYDROCHLORIDE 4()-
MDL NumberMFCD00012613
PubChem Substance ID24855992
Synonym 4-(Dimethylamino)butanoic acid hydrochloride {LY} 4-(Dimethylamino)butanoic acid hydrochloride {} {LY} 4-(Dimethylamino)butanoic acid hydrochloride {} {} {LY} 4-(Dimethylamino)butanoic acid hydrochloride {} {} {} {LY} 4-(Dimethylamino)butanoic acid hydrochloride {} {} {} {} {LY} 4-(Dimethylamino)butanoic acid hydrochloride {} {} {} {} {} {LY} 4-(Dimethylamino)butanoic acid hydrochloride {} {} {} {} {} {} {LY} 4-(Dimethylamino)butanoic acid hydrochloride {} {} {} {} {} {} {} {LY} 4-(Dimethylamino)butanoic acid hydrochloride {} {} {} {} {} {} {} {} {LY} 4-(Dimethylamino)butanoic acid hydrochloride {} {} {} {} {} {} {} {} {} {LY} 4-(Dimethylamino)butanoic acid hydrochloride {} {} {} {} {} {} {} {} {} {} {LY} 4-(Dimethylamino)butanoic acid hydrochloride {} {} {} {} {} {} {} {} {} {} {} {LY} 4-(Dimethylamino)butanoic acid hydrochloride {} {} {} {} {} {} {} {} {} {} {} {} {LY} 4-(Dimethylamino)butanoic acid hydrochloride {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 4-(Dim
Chemical Name Translation4-(二甲胺基)丁酸盐酸盐
Canonical SMILESO=C(O)CCCN(C)C.[H]Cl
GHS Symbol
Warnings IRRITANT
Safety Statements
  • S37/39 Wear suitable gloves and eye/face protection 穿戴适当的手套和眼睛/面保护；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S37 Wear suitable gloves 戴适当手套；
    Risk Statements
    • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
      Storage condition Store at room temperature {LY} Store at room temperature {} {LY} Store at room temperature {} {} {LY} Store at room temperature {} {} {} {LY} Store at room temperature {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
      WGK Germany3
      Precautionary statements
      • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
      • P305+P351+P338
        Signal word Warning
        Hazard statements
        • H315 Causes skin irritation 会刺激皮肤
        • H319 Causes serious eye irritation 严重刺激眼睛
        • H335 May cause respiratory irritation 可能导致呼吸道刺激
          Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
          Hazard Codes Xi
          Restrict
          69954-66-1 H98396 4-(Dimethylamino)butanoicacidhydrochloride 4-(二甲胺基)丁酸盐酸盐

          化学属性

          Mol. FormulaC6H14ClNO2
          Mol. Weight167.63
          Melting Point153-155°C
          TSCANo
          Danger-Level
          pH:
          Redox
          Density1.0

          *以上化合物性质及应用等信息仅供参考